Key result
In dogs with ischemic ventricular dysrhythmias, the antidysrhythmic response to lidocaine had a threshold at an ischemic myocardial tissue concentration of ≥1.0 microgram/g (P<0.005).
Why the study?
Does regional myocardial lidocaine concentration determine the antidysrhythmic effect in a dog model of coronary artery occlusion?
Population
47 anesthetized mongrel dogs
Comparison
Single IV bolus of lidocaine vs Comparison between different doses, and between…
Design
Preclinical
Authors
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Hypothesis-generating for ischemic myocardial lidocaine thresholds; does not support clinical adoption without human validation.
Does regional myocardial lidocaine concentration determine the antidysrhythmic effect in a dog model of coronary artery occlusion?
p-value: p=<0.005
In a canine model of acute ischemia, the antidysrhythmic effect of lidocaine correlates with its concentration in the ischemic myocardium rather than in normal myocardium or blood.
Davis et al. (1985) studied Ischemic ventricular dysrhythmias (n=47). Lidocaine was evaluated on Antidysrhythmic response (p=<0.005). In dogs with ischemic ventricular dysrhythmias, the antidysrhythmic response to lidocaine had a threshold at an ischemic myocardial tissue concentration of ≥1.0 microgram/g (P<0.005).
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