Key result
Captopril did not prevent the increase in blood pressure due to DOC-salt administration and failed to increase plasma or vascular renin-like activity in DOC-salt treated rats.
Why the study?
Does captopril alter plasma and vascular renin-like activity in DOC-salt hypertensive rats?
Does captopril alter plasma and vascular renin-like activity in DOC-salt hypertensive rats?
The study confirms the existence of vascular isorenin and suggests that both binding and local synthesis of the enzyme can take place in the arterial wall.
Answers are grounded in this paper and cite their sources.
Captopril ineffective in DOC-salt rat hypertension; leaves open vascular isorenin contribution to blood pressure regulation.
The presence of isorenin active at the physiological pH was investigated in DOC-salt hypertensive rats. The effect of chronic captopril treatment was analyzed in similarly treated animals and in control rats. The levels of the plasma (PRA) and vascular enzyme (VRLA) were compared with those of untreated control animals. DOC-salt administration was maintained during 4 or 8 weeks. Captopril was given in the drinking fluid beginning 4 days before DOC-salt treatment. Renin-like activity was measured in the aorta and mesenteric arteries. DOC-salt treatment reduced PRA to almost undetectable levels while aorta renin-like enzyme only decreased to 50% at 4 weeks and was not changed at 8 weeks. Isorenin levels in the mesenteric artery did not show any significant variation. Captopril did not prevent the increase in blood pressure due to DOC-salt administration and it induced a significant increase in PRA and in VRLA in control rats whereas it did not increase either - enzyme in DOC-salt treated rats. In summary these results confirm the existence of a vascular isorenin and suggest that both binding and local synthesis of the enzyme could take place in the arterial wall.
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Grinspon et al. (1985) studied DOC-salt hypertension. Captopril vs. untreated control animals was evaluated on Plasma renin activity (PRA) and vascular renin-like activity (VRLA). Captopril did not prevent the increase in blood pressure due to DOC-salt administration and failed to increase plasma or vascular renin-like activity in DOC-salt treated rats.
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