Key result
In an in vitro aortic model, TAVI devices and a surgical valve showed distinct hemodynamic properties, with peak mean kinetic energy ranging from 61 to 116 J/m3 and minimal risk for thrombus formation.
Why the study?
Cardiac implants may strongly influence circulatory hemodynamics, but the impact of TAVI devices on ascending aorta blood flow patterns under physiological conditions required in vitro investigation.
How do different TAVI devices compare to a surgical valve in terms of blood flow hemodynamics in an in vitro aortic model?
How do different TAVI devices compare to a surgical valve in terms of blood flow hemodynamics in an in vitro aortic model?
Different TAVI and surgical valve designs significantly influence aortic hemodynamics, though all tested devices demonstrated minimal risk for thrombus formation in an in vitro model.
In vitro TAVI flow alterations require clinical caution; leaves open in vivo hemodynamic validation.
Cardiac implants may have a strong influence on the hemodynamics of the circulatory system. In this study, we aimed at investigating the impact of transcatheter aortic valve implantation (TAVI) devices on blood flow patterns that develop in the ascending aorta under physiological flow conditions in vitro. For this purpose, a noninvasive optical measurement tool, three‐dimensional particle tracking velocimetry (3D‐PTV), was used in a realistic compliant silicone aortic model. The performance and the influence of two TAVIs and one surgical valve on the aortic flow were investigated. Our results showed that valve design and materials may have a distinct influence on relevant hemodynamic properties, namely kinetic energy, production of turbulence, and shear stresses in the ascending aorta. All properties varied considerably between the different valve models. We found that the total aortic regurgitation composed of the closing volume, transvalvular and paravalvular leakages varied for the three valves investigated. Furthermore, peak mean kinetic energy (MKE) ranged from 61 to 116 J/m3, whereas peak turbulent kinetic energy (TKE) ranged from 23 to 36 J/m3. The analysis of shear showed that all the three studied devices had minimal overall risk for thrombus formation. We conclude that the characteristics and material designs of TAVI devices have strong influences on the hemodynamics in the ascending aorta.
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Gülan et al. (2019) studied Aortic valve hemodynamics. Transcatheter aortic valve implantation (TAVI) devices vs. Surgical valve was evaluated on Blood flow hemodynamics (kinetic energy, turbulence, shear stresses, regurgitation). In an in vitro aortic model, TAVI devices and a surgical valve showed distinct hemodynamic properties, with peak mean kinetic energy ranging from 61 to 116 J/m3 and minimal risk for thrombus formation.
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