Key result
In spontaneously hypertensive rats, high aerobic exercise induced adverse remodeling and resulted in 67% mortality over 6 months, which was prevented by RAS inhibition with captopril.
Why the study?
Does high intensity aerobic exercise with or without captopril affect adverse cardiac remodelling and mortality in spontaneously hypertensive rats?
Does high intensity aerobic exercise with or without captopril affect adverse cardiac remodelling and mortality in spontaneously hypertensive rats?
High intensity aerobic exercise accelerates adverse cardiac remodelling and mortality in chronic pressure overloaded hearts, but concurrent RAS inhibition with captopril prevents these detrimental effects and promotes reverse remodelling.
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High-intensity exercise may harm pressure-overloaded hearts absent RAS inhibition; leaves open translation to human hypertension trials.
Rebelo et al. (2012) studied Hypertensive heart disease. Free running wheel exercise vs. Sedentary controls was evaluated on Mortality or need to be killed. In spontaneously hypertensive rats, high aerobic exercise induced adverse remodeling and resulted in 67% mortality over 6 months, which was prevented by RAS inhibition with captopril.
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