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September 19, 2012Catheterization and Cardiovascular Interventions

Transcatheter aortic valve implantation for severe regurgitation in native and degenerated bioprosthetic aortic valves

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Why the study?

Does transcatheter aortic valve implantation improve outcomes in high-risk patients with severe aortic regurgitation?

Population

8 high-risk patients with severe aortic regurgitation in native or degenerated bioprosthetic valves…

Design

Case_series

Follow-up

mean 15.5 ± 15 months

Key result

Transcatheter aortic valve implantation achieved 100% procedural success and 0% 30-day mortality in 8 high-risk patients with severe aortic regurgitation.

Authors

KSKunal SarkarGSGennaro SardellaFRFrancesco Romeo

Discussion

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Member takes

Overview

Supports TAVI feasibility in high-risk severe AR; hypothesis-generating and should not yet change practice.

Study Design

Type

Observational (n=8)

Multicenter

Yes

Structured PICO

Does transcatheter aortic valve implantation improve outcomes in high-risk patients with severe aortic regurgitation?

P
Population
8 high-risk patients (mean age 79.6 years) with severe aortic regurgitation at prohibitive risk for surgery, followed for a mean of 15.5 months.
E
Exposure
Transcatheter aortic valve implantation (TAVI) with the nitinol-based Core Valve bioprosthesis via transfemoral access.
O
Outcome
Procedural success, intraprocedural complications, in-hospital or 30-day mortality, and atrioventricular blocks requiring permanent pacemaker implantation.

TAVI with the Core Valve bioprosthesis appears feasible and safe for high-risk patients with severe aortic regurgitation, showing 100% procedural success and no 30-day mortality in a small case series.

Cite This Study

Sarkar et al. (2012) conducted an observational in Severe aortic regurgitation in native or degenerated bioprosthetic valves (n=8). Transcatheter aortic valve implantation (TAVI) with Core Valve bioprosthesis was evaluated on Procedural success. Transcatheter aortic valve implantation achieved 100% procedural success and 0% 30-day mortality in 8 high-risk patients with severe aortic regurgitation.

synapsesocial.com/papers/6a97bbe057c1a2673676fafehttps://doi.org/10.1002/ccd.24479
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1E-37 | Clinical Outcomes With Transcatheter Aortic Valve Implantation In Native and Valve-In-Valve Severe Aortic Regurgitation: Single-Center Experience2024
  2. 2Transcatheter aortic valve implantation for treatment of patients with degenerated aortic bioprostheses—valve‐in‐valve technique2010 · 52 citations
  3. 3Successful TAVI-in-TAVI for degenerated bioprosthetic aortic valve with severe stenosis-a case report2024
  4. 4Short- and mid-term safety and effectiveness of transcatheter aortic valve implantation in a failing surgical aortic bioprosthesis2012 · 7 citations
  5. 5Transcatheter Aortic Valve Implantation (TAVI) for the Treatment of Aortic Valve Stenosis: a Systematic Review2015