Key result
Amyotrophic lateral sclerosis was associated with significantly increased early myocardial T1 contrast enhancement (77.4% vs 26.7%, p=0.0001) and reduced ventricular mass compared to healthy controls.
Why the study?
Does amyotrophic lateral sclerosis affect cardiac structure and function as assessed by CMR in patients without clinical cardiac symptoms?
Population
35 patients with amyotrophic lateral sclerosis without a history of cardiac disease and 34 age and gender…
Comparison
Cardiac magnetic resonance imaging in a 1.5T… vs Age and gender matched healthy control group.
Design
Case-control
Authors
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CMR may detect subclinical cardiac changes in ALS despite normal routine tests; leaves open whether findings warrant monitoring or affect outcomes.
Case-Control (n=69)
Single-blind (image readers)
No
Does amyotrophic lateral sclerosis affect cardiac structure and function as assessed by CMR in patients without clinical cardiac symptoms?
Absolute Event Rate: 77.4% vs 26.7%
p-value: p=0.0001
ALS patients without clinical cardiac symptoms exhibit structural myocardial defects on CMR, including increased T1 enhancement and reduced ejection volumes, which may be linked to sympathetic dysfunction.
Rosenbohm et al. (2017) conducted a case-control in Amyotrophic Lateral Sclerosis (n=69). Amyotrophic Lateral Sclerosis vs. Healthy controls was evaluated on Increased myocardial T1 enhancement (p=0.0001). Amyotrophic lateral sclerosis was associated with significantly increased early myocardial T1 contrast enhancement (77.4% vs 26.7%, p=0.0001) and reduced ventricular mass compared to healthy controls.
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