Key result
Maintenance of anaesthesia with propofol resulted in a significantly greater reduction in cardiac index compared to isoflurane when turning patients prone (0.7 vs 0.4 l.min(-1).m(-2); p=0.001).
Why the study?
Does propofol total intravenous anaesthesia compared to isoflurane inhalation anaesthesia affect haemodynamic changes when turning supine to prone in patients undergoing lumbar spine surgery?
RCT (n=40)
Randomly assigned
Does propofol total intravenous anaesthesia compared to isoflurane inhalation anaesthesia affect haemodynamic changes when turning supine to prone in patients undergoing lumbar spine surgery?
Absolute Event Rate: 0.7% vs 0.4%
p-value: p=0.001
Turning healthy patients prone during surgery produces a clinically significant reduction in cardiac output, which is more pronounced during maintenance of anaesthesia with propofol compared to isoflurane.
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Propofol may warrant closer monitoring or isoflurane preference during prone positioning; extends RCT evidence on anaesthetic effects on cardiac output.
Sudheer et al. (2006) conducted an RCT in ASA I-II patients undergoing lumbar spine surgery (n=40). Propofol total intravenous anaesthesia vs. Isoflurane 1-1.2% in air was evaluated on Change in cardiac index on turning supine to prone (p=0.001). Maintenance of anaesthesia with propofol resulted in a significantly greater reduction in cardiac index compared to isoflurane when turning patients prone (0.7 vs 0.4 l.min(-1).m(-2); p=0.001).
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