Key result
Post-implantation syndrome occurred in 35% of patients undergoing EVAR for abdominal aortic aneurysms and was associated with greater increases in inflammation markers and longer hospitalization.
Why the study?
Does post-implantation syndrome following EVAR for abdominal aortic aneurysms associate with changes in inflammatory markers and clinical outcomes?
Observational (n=40)
Does post-implantation syndrome following EVAR for abdominal aortic aneurysms associate with changes in inflammatory markers and clinical outcomes?
Post-implantation syndrome is a common complication following EVAR for AAA, occurring in roughly one-third of patients, and is associated with increased systemic inflammation and prolonged hospital stays.
Post-implantation syndrome may prolong hospitalization after EVAR; hypothesis-generating for inflammation-targeted strategies in prospective trials.
OBJECTIVES: Endovascular aneurysm repair (EVAR), may elicit an unexpected systemic inflammatory response, which has been named post-implantation syndrome (PIS). The aim of this study was to prospectively evaluate the association of PIS with clinical and laboratory parameters in patients who underwent EVAR for abdominal aortic aneurysms (AAA). METHODS: Forty consecutive patients who underwent EVAR for AAA were studied. Complete blood count, fibrinogen, high sensitivity C-reactive protein (hs-CRP), interleukin (IL)-6, IL-1, tumor necrosis factor-alpha were determined before and after surgery. Several parameters regarding the operation, as well as the hospitalization days were recorded. RESULTS: PIS was diagnosed in 35% of the patients. Patients with PIS showed significant greater changes of inflammation marker levels, including hs-CRP and IL-6, as compared with the non-PIS group. PIS was associated with longer hospitalization. CONCLUSION: PIS is a relatively common complication of EVAR used to treat AAAs and it is associated with features of a systemic inflammatory response and prolongation of hospitalization. Further studies are necessary towards understanding the underlying pathophysiology and evaluating effective preventive strategies.
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Arnaoutoglou et al. (2011) conducted an observational in Abdominal aortic aneurysms (AAA) (n=40). Post-implantation syndrome (PIS) vs. Patients without PIS was evaluated on Changes in inflammation marker levels and hospitalization days. Post-implantation syndrome occurred in 35% of patients undergoing EVAR for abdominal aortic aneurysms and was associated with greater increases in inflammation markers and longer hospitalization.
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