Key result
Posthypoxic reoxygenation stimulated repetitive intracellular calcium oscillations in human aortic endothelial cells, dependent on intracellular calcium release and NAD(P)H oxidase.
Why the study?
Does posthypoxic reoxygenation stimulate intracellular calcium oscillations in human aortic endothelial cells?
Does posthypoxic reoxygenation stimulate intracellular calcium oscillations in human aortic endothelial cells?
p-value: p=<0.01
Posthypoxic reoxygenation stimulates repetitive intracellular calcium oscillations in human aortic endothelial cells, likely initiated by NAD(P)H oxidase-derived hydrogen peroxide.
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Highlights potential endothelial mechanism in reoxygenation injury; leaves open translation to clinical ischemia-reperfusion injury.
Hu et al. (2000) studied this question. Hypoxia/Reoxygenation vs. Baseline was evaluated on Intracellular calcium ([Ca(2+)](i)) oscillations (p=<0.01). Posthypoxic reoxygenation stimulated repetitive intracellular calcium oscillations in human aortic endothelial cells, dependent on intracellular calcium release and NAD(P)H oxidase.
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