Key result
Flavonoids may prevent or delay diabetic cardiomyopathy by regulating cardiac metabolism, insulin signaling, oxidative stress, apoptosis, autophagy, and inflammation.
Why the study?
The mechanistic basis of the protective effects of flavonoids in diabetic cardiomyopathy is not fully understood, with many points remaining to be clarified.
Flavonoids show potential as chemopreventive agents for diabetic cardiomyopathy by modulating multiple cellular pathways including oxidative stress and metabolism.
Hypothesis-generating for flavonoids in diabetic cardiomyopathy; randomized trials needed before clinical consideration.
Diabetic cardiomyopathy (DCM) is one of the leading causes of mortality among diabetic patients. Flavonoid are the most abundant group of phytochemicals in fruits and vegetables, and have received increasing interest as potential chemopreventive antidiabetic agents. Flavonoids might contribute to prevent or delay DCM by regulating the cardiac metabolism, insulin signaling, oxidative stress, apoptosis, autophagy, and inflammation. Among other effects, flavonoids have been proved to enhance glucose uptake, decrease cellular lipid accumulation, or suppress oxidative stress. However, the mechanistic basis of these effects is not fully understood, and many points remain to be clarified. This review provides insight into the molecular mechanisms of flavonoid chemopreventive activity by summarizing cell culture and animal model studies.
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Sonia Ramos (2025) conducted a review in Diabetic cardiomyopathy. Flavonoids was evaluated. Flavonoids may prevent or delay diabetic cardiomyopathy by regulating cardiac metabolism, insulin signaling, oxidative stress, apoptosis, autophagy, and inflammation.
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