Key result
Obesity in children with psoriasis was associated with increased serum leptin in 100% of cases compared to 14% in normal-weight controls, as well as higher mean leptin levels (16.65 vs 7.08 ng/ml).
Why the study?
Moderate to severe psoriasis cases are increasing among children, the majority of whom have obesity, and identifying relevant shared factors could help optimize biological therapy.
Does obesity increase epicardial adipose tissue thickness and serum leptin levels in children with psoriasis?
Cross-Sectional (n=12)
Does obesity increase epicardial adipose tissue thickness and serum leptin levels in children with psoriasis?
Absolute Event Rate: 100% vs 14%
In children with psoriasis, concomitant obesity is associated with elevated leptin levels and increased epicardial fat thickness.
Leptin elevation in obese children with psoriasis is hypothesis-generating; should not yet change practice or guide therapy.
Background. Psoriasis is a polygenic multifactorial immune-mediated disease. Its course can be aggravated by associated obesity. Recently, there is negative trend that is characterized by the increase in the number of moderate to severe psoriasis cases among children, and majority of them have obesity. Identification of factors that that are relevant in these two conditions will allow us to improve and optimize the genetically engineered biological therapy for this category of patients. Objective. The aim of the study is to evaluate epicardial adipose tissue thickness, serum leptin levels, eating behavior via the data from Children’s Eating Behaviour Questionnaire (CEBQ) for patients with psoriasis and obesity, and compare the results with control group – patients with psoriasis and no associated obesity. Results. We have studied 12 patients with established diagnosis of psoriasis, 5 of them had diagnosis of obesity. Epicardial fat thickening was revealed in 20% of cases in the study group (patients with psoriasis and obesity), and no epicardial fat thickening was revealed in the control group. The increase in serum leptin was revealed in 100% of cases in obese patients with psoriasis, and only in 14% of cases in the control group. The mean leptin level in obese patients was 16.65 ng/ml, in the group with normal body weight – 7.08 ng/ml. Obese patients have shown higher values in “food approach” scales group in comparison to normal weight patients. Conclusion. Patients with obesity and psoriasis has shown elevated leptin levels, higher incidence of epicardial fat thickening, and tendency to develop abnormal eating behavior.
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Ambarchyan et al. (2022) conducted a cross-sectional in Psoriasis (n=12). Obesity vs. Normal body weight was evaluated on Increase in serum leptin. Obesity in children with psoriasis was associated with increased serum leptin in 100% of cases compared to 14% in normal-weight controls, as well as higher mean leptin levels (16.65 vs 7.08 ng/ml).
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