Key result
Psoriasis is linked to significantly higher epicardial fat tissue compared to controls.
Why the study?
Several studies investigated the relationship between psoriasis and epicardial fat tissue, but each had relatively small patient numbers.
Does psoriasis associate with increased epicardial fat tissue compared to controls without psoriasis?
Meta-Analysis (n=731)
Does psoriasis associate with increased epicardial fat tissue compared to controls without psoriasis?
Patients with psoriasis have significantly higher epicardial fat tissue compared to controls, which may contribute to their increased cardiovascular risk.
Answers are grounded in this paper and cite their sources.
Psoriasis patients show higher epicardial fat; confirms association across pooled studies but leaves causal cardiovascular implications open for prospective trials.
BACKGROUND: Several studies have been performed to investigate the relationship between psoriasis and epicardial fat tissue (EFT). However, the number of patients of every single study is relatively small. OBJECTIVES: We carried out a meta-analysis to evaluate whether EFT is associated with psoriasis. METHODS: A search of PubMed, Ovid Embase, Ovid Medline, the Cochrane Library and Chinese BioMedical Literature Database (CBM) for controlled trials was done from inception to January 20th, 2016. Published trials that included a psoriasis group and a control group without psoriasis with data for at least epicardial fat tissue (EFT) were included. All statistical analyses were conducted using the Stata 12.0 (Stata Corporation, College Station, TX, USA). RESULTS: There were 5 trials involving 731 patients. Patients with psoriasis showed significantly higher EFT than control group (SMD: 0.86, 95 % CI: 0.27-1.46, P = 0.004). CONCLUSIONS: Patients with psoriasis have higher EFT compared to control subjects without psoriasis.
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Wang et al. (2016) conducted a meta-analysis in Psoriasis (n=731). Psoriasis vs. Control group without psoriasis was evaluated on Epicardial fat tissue (EFT) (SMD 0.86, 95% CI 0.27-1.46, p=0.004). Patients with psoriasis had higher epicardial fat tissue compared to control subjects without psoriasis.
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