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May 31, 2016Lipids in Health and DiseaseOpen Access

Psoriasis is linked to significantly higher epicardial fat tissue compared to controls.

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Why the study?

Several studies investigated the relationship between psoriasis and epicardial fat tissue, but each had relatively small patient numbers.

Does psoriasis associate with increased epicardial fat tissue compared to controls without psoriasis?

Population

731 patients from 5 trials including psoriasis and control groups

Comparison

Patients with psoriasis vs control subjects without psoriasis

Design

Systematic review and meta-analysis of controlled trials

Key result

Patients with psoriasis had significantly higher epicardial fat tissue compared to control subjects without psoriasis (SMD 0.86).

Authors

XWXiaoxue WangZGZaipei GuoZZZexin Zhu

Discussion

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Overview

Psoriasis patients show higher epicardial fat; confirms association across pooled studies but leaves causal cardiovascular implications open for prospective trials.

Study Design

Type

Meta-Analysis (n=731)

Structured PICO

Does psoriasis associate with increased epicardial fat tissue compared to controls without psoriasis?

P
Population
731 patients from 5 trials comparing epicardial fat tissue between patients with psoriasis and control subjects without psoriasis.
E
Exposure
Psoriasis (exposure)
C
Comparator
Control subjects without psoriasis
O
Outcome
Epicardial fat tissue (EFT)surrogate

Main Result

Standardized Mean Difference: 0.86 (95% CI 0.27–1.46)

p-value: p=0.004

Patients with psoriasis have significantly higher epicardial fat tissue compared to controls, which may contribute to their increased cardiovascular risk.

Limitations

  • Small sample size in three of the included studies
  • All included studies were cross-sectional in design without clinical follow-up
  • Echocardiography was used in some studies, which is less accurate than the gold standard MRI
  • Great heterogeneity of EFT between trials, likely caused by differences in measurement technology

Cite This Study

Wang et al. (2016) conducted a meta-analysis in Psoriasis (n=731). Psoriasis vs. Control group without psoriasis was evaluated on Epicardial fat tissue (EFT) (SMD 0.86, 95% CI 0.27-1.46, p=0.004). Patients with psoriasis had significantly higher epicardial fat tissue compared to control subjects without psoriasis (SMD 0.86).

synapsesocial.com/papers/6aaa0da95da1df3164844cfdhttps://doi.org/10.1186/s12944-016-0271-y
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Epicardial Adipose Tissue and Psoriasis: A Systematic Review and Meta-Analysis2024 · 7 citations
  2. 2Patients with psoriasis have an increased amount of epicardial fat tissue2013 · 26 citations
  3. 3Increased epicardial fat tissue is a marker of subclinical atherosclerosis in patients with psoriasis2013 · 45 citations
  4. 4Epicardial Fat: A New Therapeutic Target in Psoriasis2019 · 11 citations
  5. 5Association between Epicardial Adipose Tissue Thickness and Clinical and Metabolic Parameters in Patients with Psoriasis and Psoriatic Arthritis: A Cross-Sectional Study from Türkiye2026