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August 5, 2013British Journal of Dermatology

Patients with psoriasis had significantly increased epicardial fat thickness (7.3 vs. 6.5 mm, P<0.01) and carotid intima-media thickness (0.74 vs. 0.60 mm, P<0.01) compared to matched controls.

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Why the study?

Does epicardial fat thickness correlate with carotid intima-media thickness as a marker of subclinical atherosclerosis in patients with psoriasis?

Population

65 patients with psoriasis and 50 age- and sex-matched control subjects

Comparison

Echocardiographic measurement of epicardial fat… vs Age- and sex-matched control subjects

Design

Cross-sectional

Key result

Patients with psoriasis had significantly increased epicardial fat thickness (7.3 vs. 6.5 mm, P<0.01) and carotid intima-media thickness (0.74 vs. 0.60 mm, P<0.01) compared to matched controls.

Authors

BSBarsha SenEREmine Nur RifaioğluÖEÖzlem Ekiz

Discussion

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Member takes

Overview

Supports EFT as a marker of subclinical atherosclerosis in psoriasis; hypothesis-generating and requires prospective validation.

Study Design

Type

Cross-Sectional (n=115)

Structured PICO

Does epicardial fat thickness correlate with carotid intima-media thickness as a marker of subclinical atherosclerosis in patients with psoriasis?

P
Population
115 participants, including 65 patients with psoriasis and 50 age- and sex-matched controls, evaluated for epicardial fat thickness and carotid intima-media thickness.
E
Exposure
Echocardiographic measurement of epicardial fat thickness (EFT)
C
Comparator
Age- and sex-matched control subjects
O
Outcome
Association between epicardial fat thickness (EFT) and carotid intima-media thickness (CIMT)surrogate

Main Result

Absolute Event Rate: 7.3% vs 6.5%

p-value: p=<0.01

Echocardiographic epicardial fat thickness is increased and correlates with carotid intima-media thickness in patients with psoriasis, suggesting its utility as a simple marker of subclinical atherosclerosis.

Cite This Study

Sen et al. (2013) conducted a cross-sectional in Psoriasis (n=115). Psoriasis vs. Age- and sex-matched controls was evaluated on Epicardial fat thickness (EFT) (p=<0.01). Patients with psoriasis had significantly increased epicardial fat thickness (7.3 vs. 6.5 mm, P<0.01) and carotid intima-media thickness (0.74 vs. 0.60 mm, P<0.01) compared to matched controls.

synapsesocial.com/papers/6ab8b58cbc9fe79e22fc6c4dhttps://doi.org/10.1111/bjd.12569
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Patients with psoriasis have an increased amount of epicardial fat tissue2013 · 26 citations
  2. 2Carotid intima-media thickness and epicardial fat thickness predict precoronary artery disease status in psoriasis2021 · 14 citations
  3. 3Epicardial adipose tissue and coronary artery calcification in psoriasis patients2014 · 46 citations
  4. 4Epicardial fat tissue in patients with psoriasis:a systematic review and meta-analysis2016 · 42 citations
  5. 5Epicardial Adipose Tissue and Psoriasis: A Systematic Review and Meta-Analysis2024 · 7 citations