Key result
Intraoperative vasopressor dose on bypass was significantly associated with mesenteric ischaemia mortality following cardiac surgery (OR 1.28; 95% CI 1.04-1.57; P=0.02).
Why the study?
Are intraoperative perfusion parameters and vasopressor use associated with mesenteric ischaemia mortality in patients undergoing cardiac surgery?
Population
10,409 patients who underwent cardiac surgery between 2006 and 2011 at Papworth Hospital, from which 3…
Comparison
Intraoperative perfusion parameters and… vs Patients who died of non-MesI causes and…
Design
Case-control
Follow-up
until discharge
Authors
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May warrant caution with vasopressor dosing on bypass; leaves open whether perfusion optimization reduces mesenteric ischaemia mortality.
Case-Control (n=10,409)
No
Are intraoperative perfusion parameters and vasopressor use associated with mesenteric ischaemia mortality in patients undergoing cardiac surgery?
Odds Ratio: 1.28 (95% CI 1.04–1.57)
p-value: p=0.02
Intraoperative vasopressor use and lower mean arterial pressure during cardiopulmonary bypass are associated with increased mortality from mesenteric ischaemia after cardiac surgery.
Sastry et al. (2014) conducted a case-control in Cardiac surgery (n=10,409). Intraoperative vasopressor use vs. Lower or no vasopressor use was evaluated on Mesenteric ischaemia mortality (OR 1.28, 95% CI 1.04-1.57, p=0.02). Intraoperative vasopressor dose on bypass was significantly associated with mesenteric ischaemia mortality following cardiac surgery (OR 1.28; 95% CI 1.04-1.57; P=0.02).
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