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Experimental study reveals Cotinus coggygria extract prevents ethanol-induced oxidative stress in rat brain tissue, suggesting protective neurochemical benefits.
Cotinus coggygria Scop. (C. coggygria) has been reported to contain numerous secondary metabolites. In the present study, in vitro total phenolic and flavonoid contents and antioxidant activity of C. coggygria extract were determined. In in vivo experiments, rats were divided into four groups. Total oxidant and antioxidant status, nitric oxide, reduced glutathione, lipid peroxidation, sialic acid, advanced oxidized protein product levels and carbonic anhydrase, aryl esterase, xanthine oxidase, lactate dehydrogenase, paraoxonase, prolidase, acetylcholinesterase enzyme activities and antioxidant and glutathione-related enzyme activities were determined in all brain tissue homogenates. According to the results, aqueous C. coggygria extract shows protective properties against ethanol-induced brain damage due to various bioactive components it contains and provides restoration of biochemical parameters. Considering the data from our study, C. coggygria can be used to prevent ethanol-induced oxidative stress in brain tissue due to its strong antioxidant activity.
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ALTIN et al. (2026) studied this question.
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