Experimental study reveals Cotinus coggygria extract prevents ethanol-induced oxidative stress in rat brain tissue, suggesting protective neurochemical benefits.
Key Points
To determine the in vitro antioxidant profile of Cotinus coggygria extract and investigate its potential to prevent ethanol-induced oxidative brain damage in rats.
Quantified total phenolic and flavonoid concentrations along with in vitro antioxidant activity of aqueous Cotinus coggygria extract.
Assigned rats across four experimental groups to assess neuroprotective effects following ethanol exposure and extract administration.
Analyzed total oxidant and antioxidant status, lipid peroxidation, reduced glutathione, advanced oxidized protein products, and neuro-metabolic enzyme activities in brain homogenates.
Aqueous Cotinus coggygria extract demonstrated high total phenolic and flavonoid content and exerted strong in vitro antioxidant activity.
Extract treatment prevented ethanol-induced oxidative neurotoxicity, markedly reducing lipid peroxidation and protein oxidation products while elevating reduced glutathione and antioxidant enzyme levels.
Administration of the extract restored altered regulatory and metabolic enzyme activities, including acetylcholinesterase, toward baseline physiological levels in brain tissue.