What does this research mean for the field?

Sinensetin alleviates LPS-induced acute pneumonia by reducing inflammation and oxidative stress through the suppression of the HIF-1α signaling pathway. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To elucidate the therapeutic mechanisms by which sinensetin alleviates lipopolysaccharide-induced acute pneumonia in in vivo and in vitro models.

September 2, 2026eFoodOpen Access

Sinensetin From Citrus Peel Alleviates LPS‐Induced Acute Pneumonia by Regulating HIF‐1α Signaling Pathway in Mice

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Authors

ZHZuomin Hu YWYuchi Wu FLFeijun Luo

Discussion

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Overview

Preclinical study demonstrates sinensetin attenuates lipopolysaccharide-induced acute pneumonia in mice and lung cells, indicating therapeutic potential via HIF-1α pathway inhibition.

Key Points

To elucidate the therapeutic mechanisms by which sinensetin alleviates lipopolysaccharide-induced acute pneumonia in in vivo and in vitro models.
Established lipopolysaccharide (LPS)-induced acute pneumonia models in mice treated with sinensetin for 3 days and in vitro using LPS-stimulated BEAS-2B human bronchial epithelial cells.
Evaluated lung pathology, oxidative stress, and inflammatory mediators using transcriptomic analysis, Western blotting for HIF-1α and MAPK phosphorylation, and HIF-1α overexpression rescue experiments.
Sinensetin administration significantly attenuated LPS-induced lung injury, oxidative stress, and inflammation in mice, suppressing HIF-1α expression and MAPK (p38, ERK1/2, JNK) phosphorylation.
In BEAS-2B cells, sinensetin mitigated morphological damage, reactive oxygen species accumulation, NF-κB and AP-1 transcriptional activity, and inflammatory factors, whereas HIF-1α overexpression reversed these protective effects.

Cite This Study

Hu et al. (2026) studied this question.

synapsesocial.com/papers/6a97e2f6c562ede874ec7796 https://doi.org/10.1002/efd2.70203

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September 2, 2026eFoodOpen Access

Sinensetin From Citrus Peel Alleviates LPS‐Induced Acute Pneumonia by Regulating HIF‐1α Signaling Pathway in Mice

View Full Paper

Ask AI

Bookmark

Authors

ZHZuomin Hu YWYuchi Wu FLFeijun Luo

Discussion

Member takes

Overview

Preclinical study demonstrates sinensetin attenuates lipopolysaccharide-induced acute pneumonia in mice and lung cells, indicating therapeutic potential via HIF-1α pathway inhibition.

Key Points

To elucidate the therapeutic mechanisms by which sinensetin alleviates lipopolysaccharide-induced acute pneumonia in in vivo and in vitro models.
Established lipopolysaccharide (LPS)-induced acute pneumonia models in mice treated with sinensetin for 3 days and in vitro using LPS-stimulated BEAS-2B human bronchial epithelial cells.
Evaluated lung pathology, oxidative stress, and inflammatory mediators using transcriptomic analysis, Western blotting for HIF-1α and MAPK phosphorylation, and HIF-1α overexpression rescue experiments.
Sinensetin administration significantly attenuated LPS-induced lung injury, oxidative stress, and inflammation in mice, suppressing HIF-1α expression and MAPK (p38, ERK1/2, JNK) phosphorylation.
In BEAS-2B cells, sinensetin mitigated morphological damage, reactive oxygen species accumulation, NF-κB and AP-1 transcriptional activity, and inflammatory factors, whereas HIF-1α overexpression reversed these protective effects.

Cite This Study

Hu et al. (2026) studied this question.

synapsesocial.com/papers/6a97e2f6c562ede874ec7796 https://doi.org/10.1002/efd2.70203

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