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November 11, 2025Journal of Agricultural and Food Chemistry

Sinensetin Ameliorates Lipopolysaccharide-Induced Liver Injury by Targeting the TLR4/NF-κB/NLRP3 Pathway and Related Gut–Liver Axis Dysfunction in Mice

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Authors

ZMZhuoqun MengQZQin ZhangRZRanran Zhang

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Overview

Animal study shows sinensetin alleviates liver injury via TLR4/NF-κB/NLRP3 pathway and enhances gut microbiota balance.

Key Points

  • This research investigates the effects of sinensetin on LPS-induced liver injury in a mouse model.
  • Mouse model established for LPS-induced liver injury.
  • Sinensetin administered to assess its impact on liver and intestinal health.
  • Histopathological examination of liver and intestinal tissues.
  • Analysis of gut microbiota composition and SCFA levels.
  • Sinensetin improved liver injury symptoms and intestinal health.
  • Histopathological changes were restored in liver and intestine.
  • LPS-induced activation of TLR4/NF-κB/NLRP3 pathway was inhibited.
  • Gut microbiota dysbiosis and SCFA levels were positively modified.

Cite This Study

Meng et al. (2025) studied this question.

synapsesocial.com/papers/69252ea3c0ce034ddc356886https://doi.org/10.1021/acs.jafc.5c07080
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Also Consider

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