What does this research mean for the field?

Open anterior skull base reconstruction following oncologic resection is feasible using defect-specific multilayer closure and vascularized tissue coverage, though existing retrospective evidence is insufficient to establish the superiority of any single reconstructive technique. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To systematically evaluate surgical techniques and postoperative clinical outcomes for open anterior skull base reconstruction following oncologic resection.

September 2, 2026Journal of Craniofacial Surgery

Reconstructing the Anterior Skull Base After Oncologic Resection: A Comprehensive Systematic Review of Open Techniques and Outcomes

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Authors

LCLeonardo Januário Campos Cardoso MFMárcio Yuri Ferreira MSMurtaja Satea

Discussion

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Overview

Systematic review reveals feasible open reconstruction outcomes after tumor resection, highlighting low flap failure and cerebrospinal fluid leak rates across diverse defect-specific strategies.

Key Points

To systematically evaluate surgical techniques and postoperative clinical outcomes for open anterior skull base reconstruction following oncologic resection.
PRISMA-guided systematic search across PubMed, Embase, Cochrane Library, and Web of Science through December 2025.
Included English-language original studies on open anterior skull base reconstruction following oncologic resection reporting reconstructive approaches and outcomes (N = 27 studies, comprising 554 cases/procedures: 17 retrospective studies and 10 case reports).
Reconstructive techniques included pedicled regional flaps (12 studies), free microvascular flaps (7 studies), non-vascularized free grafts (4 studies), mixed approaches (2 studies), artificial dural grafts (1 study), and autologous composite grafts (1 study).
Dural patch grafts were utilized in 18 studies (with watertight closure explicitly reported in 12), bone grafts in 12 studies, and titanium mesh in 7 studies.
Flap survival was reported across 20 studies with 9 total flap failures; cerebrospinal fluid leaks occurred in 9 of 26 reporting studies, with a peak cohort leak rate of 11.8%, and revision surgery occurred in 10 of 24 reporting studies.

Cite This Study

Cardoso et al. (2026) studied this question.

synapsesocial.com/papers/6a97e305c562ede874ec7948 https://doi.org/10.1097/scs.0000000000013345

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September 2, 2026Journal of Craniofacial Surgery

Reconstructing the Anterior Skull Base After Oncologic Resection: A Comprehensive Systematic Review of Open Techniques and Outcomes

View Full Paper

Ask AI

Bookmark

Authors

LCLeonardo Januário Campos Cardoso MFMárcio Yuri Ferreira MSMurtaja Satea

Discussion

Member takes

Overview

Systematic review reveals feasible open reconstruction outcomes after tumor resection, highlighting low flap failure and cerebrospinal fluid leak rates across diverse defect-specific strategies.

Key Points

To systematically evaluate surgical techniques and postoperative clinical outcomes for open anterior skull base reconstruction following oncologic resection.
PRISMA-guided systematic search across PubMed, Embase, Cochrane Library, and Web of Science through December 2025.
Included English-language original studies on open anterior skull base reconstruction following oncologic resection reporting reconstructive approaches and outcomes (N = 27 studies, comprising 554 cases/procedures: 17 retrospective studies and 10 case reports).
Reconstructive techniques included pedicled regional flaps (12 studies), free microvascular flaps (7 studies), non-vascularized free grafts (4 studies), mixed approaches (2 studies), artificial dural grafts (1 study), and autologous composite grafts (1 study).
Dural patch grafts were utilized in 18 studies (with watertight closure explicitly reported in 12), bone grafts in 12 studies, and titanium mesh in 7 studies.
Flap survival was reported across 20 studies with 9 total flap failures; cerebrospinal fluid leaks occurred in 9 of 26 reporting studies, with a peak cohort leak rate of 11.8%, and revision surgery occurred in 10 of 24 reporting studies.

Cite This Study

Cardoso et al. (2026) studied this question.

synapsesocial.com/papers/6a97e305c562ede874ec7948 https://doi.org/10.1097/scs.0000000000013345

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Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

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