Key result
Invasive breast cancer was associated with a significantly higher rate of venous thromboembolism compared to benign breast disease or carcinoma in situ in women undergoing breast surgery.
Why the study?
Breast cancer contributes to many VTE events because it is the most commonly diagnosed tumor in women, prompting analysis of the occurrence, timing, risk factors, and survival impact of VTE following breast surgery.
Does invasive breast cancer increase the risk of venous thromboembolism and impact survival compared to benign breast disease in female patients undergoing breast surgery?
Cohort (n=5,039)
No
Does invasive breast cancer increase the risk of venous thromboembolism and impact survival compared to benign breast disease in female patients undergoing breast surgery?
Invasive breast cancer, along with factors like hypertension and high BMI, significantly increases the risk of VTE in women undergoing breast surgery, which in turn negatively impacts survival.
Answers are grounded in this paper and cite their sources.
Heightened VTE vigilance may be considered in invasive breast cancer; leaves open whether prophylaxis improves survival.
Albeit it does not have the highest venous thromboembolism (VTE) incidence compared to other neoplasms, breast cancer contributes to many VTE events because it is the most diagnosed tumor in women. We aim to analyze the occurrence and timing of VTE during the follow-up of patients who underwent breast surgery, the possible correlated factors, and the overall survival. This retrospective study included all female patients diagnosed with mammary pathology and surgically treated in our clinic between January 2002 and January 2012. Of 5039 women who underwent breast surgery, 1056 were found to have no evidence of malignancy, whereas 3983 were diagnosed with breast cancer. VTE rate resulted significantly higher in patients with invasive breast cancer than in women with benign breast disease or carcinoma in situ. Invasive cancers other than lobular or ductal were associated with a higher VTE rate. In addition, chronic hypertension, high BMI, cancer type, and evidence of metastasis turned out to be the most significant risk factors for VTE in women who underwent breast surgery. Moreover, VTE occurrence significantly impacted survival in invasive breast cancer patients. Compared to women with benign mammary pathology, VTE prevalence in women with breast cancer is significantly higher. The knowledge about the risk factors of VTE could be helpful as prognostic information, but also to eventually target preventive treatment strategies for VTE, as far as the co-existence of invasive breast cancer and VTE has a significantly negative impact on survival.
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Londero et al. (2022) conducted a cohort in Mammary pathology / Breast cancer (n=5,039). Invasive breast cancer vs. Benign breast disease or carcinoma in situ was evaluated on Venous thromboembolism (VTE) rate. Invasive breast cancer was associated with a significantly higher rate of venous thromboembolism compared to benign breast disease or carcinoma in situ in women undergoing breast surgery.
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