Key result
Ivabradine (3 μM) significantly reduced heart rate by 35 ± 5% and increased stroke volume by 39 ± 9% while preserving energy substrate metabolism in ex vivo healthy normoxic working mouse hearts.
Why the study?
Does ivabradine reduce heart rate while preserving energy substrate metabolism compared to metoprolol in an ex vivo mouse heart model?
Population
Ex vivo healthy normoxic working mouse hearts (n=20; 10 controls, 10 ivabradine)
Comparison
Ivabradine (3 μM) with or without atrial pacing vs Control and metoprolol
Design
Preclinical
Authors
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Ivabradine may preserve metabolism better than metoprolol in healthy hearts; leaves open translation to diseased or in vivo models.
Does ivabradine reduce heart rate while preserving energy substrate metabolism compared to metoprolol in an ex vivo mouse heart model?
Ivabradine selectively reduces heart rate while preserving cardiac energy substrate metabolism in healthy working mouse hearts, unlike metoprolol which impairs both cardiac function and glycolysis.
Lauzier et al. (2011) studied Healthy normoxic working hearts (n=20). Ivabradine vs. Control (absence of ivabradine) and Metoprolol was evaluated on Heart rate, stroke volume, and metabolic fluxes. Ivabradine (3 μM) significantly reduced heart rate by 35 ± 5% and increased stroke volume by 39 ± 9% while preserving energy substrate metabolism in ex vivo healthy normoxic working mouse hearts.
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