July 1, 1970Cardiovascular Research
Arteriovenous potassium changes and ventricular arrhythmias after coronary artery occlusion
Authors
Discussion
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Implication
Anatomic occlusion site outweighs local potassium rise for canine ventricular arrhythmias; leaves open mechanistic relevance to human acute coronary syndromes.
Key Points
- Investigate the relationship between coronary venous potassium release, arterial occlusion site, and the onset of ventricular arrhythmias following acute coronary obstruction.
- Occluded the anterior descending coronary artery or its individual branches (anterolateral, apical, or terminal branches) in canine models.
- Measured local coronary venous potassium discharge and monitored the subsequent development of ventricular arrhythmias.
- Potassium discharged into local accompanying veins following occlusion of either the main anterior descending coronary artery or its branches.
- Serious ventricular arrhythmias occurred frequently following occlusion of the descending artery or its terminal branch, but did not occur after occlusion of anterolateral or apical branches.
- Anatomical site of vascular occlusion exerted a greater influence on early arrhythmogenesis than increases in coronary venous potassium concentration.
Cite This Study
Shulman et al. (1970) studied this question.