Key result
An increase in Angiopoietin-2 at 24 hours post-cardiopulmonary bypass was highly correlated with hospital length of stay (rho = 0.590; p < 0.0001).
Cohort
Effect estimate: rho = 0.590
p-value: p=< 0.0001
Angiopoietin-2 increase at 24 hours post-cardiopulmonary bypass correlates significantly with hospital length of stay, suggesting its potential utility as an early biomarker for vascular leakage.
AIM: Vascular leakage following cardiopulmonary bypass contributes to morbidity. Angiopoietin-1 and -2 are biomarkers of endothelial dysfunction. Our aim was to characterize Ang-1 and -2 association with clinical characteristics and outcomes. METHODS: Observational cohort study measuring Ang-1/-2 with a panel of cytokines in adults undergoing cardiopulmonary bypass. RESULTS: Ang-2 levels increased immediately postop whereas Ang-1 levels decreased over time. No significant correlation was found with other inflammatory mediators. High correlation was found between the hospital length of stay and Ang-2 increase at 24 h (rho = 0.590; p < 0.0001). The predictors of Ang-2 increase were female gender, cross clamp time, transfusion of blood and absence of angiotensin-converting enzyme inhibitor as a pre-op medication. CONCLUSION: Angiopoietins can detect vascular leakage early and could impact patient's management to decrease length of stay after cardiac surgery.
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Charbonney et al. (2017) conducted a cohort in Cardiopulmonary bypass. Angiopoietin-1 and -2 levels was evaluated on Hospital length of stay (rho = 0.590, p=< 0.0001). An increase in Angiopoietin-2 at 24 hours post-cardiopulmonary bypass was highly correlated with hospital length of stay (rho = 0.590; p < 0.0001).
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