Key result
Impaired stress-induced pressure natriuresis in African American youths led to an extended period of elevated blood pressure (P<0.05) driven by a volume-mediated increase in BP (r=0.55, P<0.002).
Why the study?
Does impaired stress-induced pressure natriuresis increase blood pressure load in African American youths?
Observational (n=118)
Does impaired stress-induced pressure natriuresis increase blood pressure load in African American youths?
p-value: p=<.05
Impaired stress-induced pressure natriuresis leads to a volume-mediated extended elevation in blood pressure, which may contribute to the development of essential hypertension in African American youths.
May heighten hypertension risk in African American youths; hypothesis-generating and requires longitudinal confirmation.
BACKGROUND: We hypothesized that impaired stress-induced pressure natriuresis increases blood pressure (BP) load. METHODS: The 118 African American youths were brought into similar levels of sodium balance. The protocol consisted of a 2-h baseline period, a 1-h stress period (competitive video games), and a 2-h recovery period. RESULTS: Normal pressure natriuresis (n = 80) resulted from a resistance-mediated (r = 0.23; P <.03) increase in BP (P <.001). In contrast, impaired pressure natriuresis (n = 38), leading to an extended period of elevated BP (P <.05), resulted from a volume-mediated (r = 0.55; P <.002) increase in BP (P <.001). CONCLUSIONS: Impaired stress-induced pressure natriuresis may contribute to the development of essential hypertension, particularly in African Americans.
No takes yet. Share an insight, caveat, or question.
Gregory A. Harshfield (2002) conducted an observational in Cardiovascular load / Blood pressure regulation (n=118). Impaired stress-induced pressure natriuresis vs. Normal pressure natriuresis was evaluated on Extended period of elevated blood pressure (p=<.05). Impaired stress-induced pressure natriuresis in African American youths led to an extended period of elevated blood pressure (P<0.05) driven by a volume-mediated increase in BP (r=0.55, P<0.002).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: