Key result
The affinity of yeast profilin for rabbit actin (2.9 microM) was approximately 30-fold weaker than the affinity of human platelet profilin for rabbit actin (0.1 microM).
Population
Saccharomyces cerevisiae profilin, human platelet profilin, rabbit skeletal muscle actin, and yeast actin
Design
Preclinical
Authors
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Yeast models may not reflect human profilin function; leaves open questions on species-specific cytoskeletal regulation.
Absolute Event Rate: 2.9% vs 0.1%
The structure of yeast profilin is similar to other profilins, but its affinity for actin and efficiency in catalyzing nucleotide exchange differ significantly from human profilin.
Eads et al. (1998) studied this question. Yeast profilin vs. Human platelet profilin was evaluated on Affinity for rabbit skeletal muscle actin. The affinity of yeast profilin for rabbit actin (2.9 microM) was approximately 30-fold weaker than the affinity of human platelet profilin for rabbit actin (0.1 microM).
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