Key result
Temazepam, clonidine, and timolol as preanesthetic medications all reduced preoperative anxiety compared to placebo, with neither clonidine nor timolol offering major advantages over temazepam.
Why the study?
Do temazepam, clonidine, or timolol reduce preoperative anxiety compared to placebo in patients undergoing minor orthopedic surgery?
Population
Patients undergoing minor orthopedic surgery
Comparison
Temazepam, clonidine, or timolol as… vs Placebo
Design
RCT, randomized, double-blind
Follow-up
early postoperative period (up to 90 min)
Authors
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Supports temazepam for preoperative anxiolysis; confirms no major advantage of clonidine or timolol in minor orthopedic surgery.
RCT
double-blind
randomized
Do temazepam, clonidine, or timolol reduce preoperative anxiety compared to placebo in patients undergoing minor orthopedic surgery?
Temazepam, clonidine, and timolol effectively reduce preoperative anxiety compared to placebo, but adrenergic modulators offer no major advantage over temazepam.
CARABINE et al. (1991) conducted an RCT in Preoperative anxiety. Temazepam, clonidine, and timolol vs. Placebo was evaluated on Preoperative anxiety. Temazepam, clonidine, and timolol as preanesthetic medications all reduced preoperative anxiety compared to placebo, with neither clonidine nor timolol offering major advantages over temazepam.
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