April 27, 2007Diabetes Care
Endothelial Function Varies According to Insulin Resistance Disease Type
Key result
Type 2 diabetes was associated with reduced flow-mediated vasodilation (3.4%) compared to healthy controls (7.3%), whereas lipodystrophic diabetes and PCOS were not (P=0.005).
Why the study?
Does endothelial function vary according to the type of insulin resistance disease?
Population
47 women, including 12 with type 2 diabetes, 6 with non-HIV lipodystrophic diabetes, 10 with nondiabetic…
Comparison
Insulin resistance states vs Healthy female control subjects
Design
Cross-sectional
Authors
Discussion
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Implication
Endothelial dysfunction appears selective to type 2 diabetes among insulin-resistant states; supports distinct mechanisms but leaves open prospective validation.
Study Design
Type
Observational (n=47)
Structured PICO
Does endothelial function vary according to the type of insulin resistance disease?
P
Population
47 female subjects, including those with type 2 diabetes, lipodystrophic diabetes, PCOS, and healthy controls, evaluated for endothelial function.
E
Exposure
Insulin resistance states (type 2 diabetes, non-HIV lipodystrophic diabetes, and nondiabetic PCOS)
C
Comparator
Healthy female control subjects
O
Outcome
Endothelium-dependent and -independent vasodilation measured by high-resolution B-mode ultrasoundsurrogate
Main Result
Absolute Event Rate: 3.4% vs 7.3%
p-value: p=0.005
Abnormal endothelium-dependent vasodilation is present in patients with type 2 diabetes but not in other insulin-resistant states like lipodystrophic diabetes or PCOS, suggesting different mechanisms of insulin resistance affect endothelial function differently.
Cite This Study
Beckman et al. (2007) conducted an observational in Insulin resistance (n=47). Type 2 diabetes, lipodystrophic diabetes, and PCOS vs. Healthy control subjects was evaluated on Flow-mediated vasodilation (p=0.005). Type 2 diabetes was associated with reduced flow-mediated vasodilation (3.4%) compared to healthy controls (7.3%), whereas lipodystrophic diabetes and PCOS were not (P=0.005).