Differing Pattern of Sympathoexcitation in Normal-Weight and Obesity-Related Hypertension
Key result
Normal-weight hypertension involved increased firing rates of single sympathetic fibers (70 vs 28 spikes/100 beats; P<0.001), whereas obesity-related hypertension involved recruitment of silent fibers.
Why the study?
Does the pattern of sympathetic activation differ between normal-weight and obesity-related hypertension?
Population
46 individuals, comprising normal-weight hypertensive, obesity-related hypertensive, normal-weight…
Design
Cross-sectional
Authors
Discussion
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Implication
Supports distinct sympathetic mechanisms by hypertension phenotype; hypothesis-generating for targeted sympathomodulation.
Study Design
Type
Observational (n=46)
Structured PICO
Does the pattern of sympathetic activation differ between normal-weight and obesity-related hypertension?
P
Population
46 individuals comprising normal-weight and obese patients with hypertension, and normal-weight and obese normotensive controls.
O
Outcome
Multiunit and single fiber sympathetic nerve firing propertiessurrogate
Main Result
Absolute Event Rate: 65% vs 47%
p-value: p=<0.01
The pattern of sympathetic activation differs between normal-weight and obesity-related hypertension, suggesting distinct underlying central nervous system mechanisms.
Cite This Study
Lambert et al. (2007) conducted an observational in Hypertension (n=46). Hypertension vs. Normal blood pressure was evaluated on Total multiunit muscle sympathetic nerve activity in normal-weight groups (bursts per 100 heartbeats) (p=<0.01). Normal-weight hypertension involved increased firing rates of single sympathetic fibers (70 vs 28 spikes/100 beats; P<0.001), whereas obesity-related hypertension involved recruitment of silent fibers.