Why the study?
Does candesartan improve endothelial function in patients with essential hypertension?
Population
15 patients with essential hypertension and 15 control subjects (n=30)
Comparison
Candesartan cilexetil 8 to 16 mg daily for 12… vs Baseline values and healthy control subjects
Design
Cohort
Follow-up
12 months
Authors
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Candesartan may enhance endothelial function in hypertension; leaves open clinical outcome benefits pending randomized trials.
Does candesartan improve endothelial function in patients with essential hypertension?
Candesartan improves endothelial function in essential hypertension by enhancing tonic nitric oxide release and reducing endothelin-1-induced vasoconstriction.
Ghiadoni et al. (2000) studied this question.
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