Key result
The rare variant of ANK2 polymorphism rs6850768 significantly shortened the QT interval by 3.79 ms (95% CI, 1.48-5.58; P=0.001) in homozygotes in the KORA S3 general population.
Why the study?
Do common genetic variants in the ANK2 gene modulate the corrected QT interval length in the general population?
Population
5,078 participants from the general population
Comparison
Common genetic variants in the ANK2 gene vs Absence of these specific genetic variants
Design
Cross-sectional
Authors
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ANK2 variant rs6850768 was associated with shorter QT; supports ankyrin-B role in repolarization but leaves clinical relevance open.
Observational (n=5,078)
Yes
Do common genetic variants in the ANK2 gene modulate the corrected QT interval length in the general population?
Mean Difference: 3.79 (95% CI 1.48–5.58)
p-value: p=0.001
Common genetic variants in the ANK2 gene are associated with significant modulation of the QT interval length in the general population, supporting the role of ankyrin-B in normal cardiac electrical activity.
Sedláček et al. (2008) conducted an observational in General population (n=5,078). ANK2 genetic variant rs6850768 vs. Non-carriers (wild-type) was evaluated on Duration of the QT interval (3.79 ms shortening, 95% CI 1.48 to 5.58, p=0.001). The rare variant of ANK2 polymorphism rs6850768 significantly shortened the QT interval by 3.79 ms (95% CI, 1.48-5.58; P=0.001) in homozygotes in the KORA S3 general population.
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