Key result
Global genetic indices of African ancestry were not associated with QT interval duration (P=0.94), while significant associations were identified with SNPs at NOS1AP and ATP1B1 loci.
Why the study?
Are African ancestry and common genetic variants associated with prolonged QT interval in African Americans?
Population
African Americans from population-based cohorts
Design
Cross-sectional
Authors
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Global ancestry indices need not inform QT assessment in African Americans; extends specific European loci to this population but leaves broader effects open.
Observational (n=13,105)
Yes
Are African ancestry and common genetic variants associated with prolonged QT interval in African Americans?
p-value: p=0.94
Global genetic indices of African ancestry do not explain differences in cardiac repolarization duration, but specific genetic loci associated with QT interval in European populations also apply to African Americans.
Smith et al. (2012) conducted an observational in QT interval prolongation (n=13,105). African ancestry and common genetic variants was evaluated on QT interval duration (p=0.94). Global genetic indices of African ancestry were not associated with QT interval duration (P=0.94), while significant associations were identified with SNPs at NOS1AP and ATP1B1 loci.
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