Key result
An inter-arm systolic blood pressure difference ≥ 10 mmHg was associated with an increased risk of cardiovascular mortality compared to < 10 mmHg (HR 1.58; 95% CI 1.3-1.93).
Why the study?
Does an inter-arm systolic blood pressure difference ≥ 10 mmHg or ≥ 15 mmHg increase the risk of cardiovascular mortality?
Meta-Analysis
Does an inter-arm systolic blood pressure difference ≥ 10 mmHg or ≥ 15 mmHg increase the risk of cardiovascular mortality?
An inter-arm systolic blood pressure difference of ≥10 mmHg or ≥15 mmHg is significantly associated with an increased risk of cardiovascular mortality, serving as a useful clinical marker to identify high-risk patients.
The inter-arm systolic blood pressure difference (SBPD) is recommended to be in relation to potential cardiovascular disease (CVD). Previous studies yielded controversial results about the association between an inter-arm SBPD ≥ 10 mmHg or ≥15 mmHg and the risk of cardiovascular mortality. Therefore, we conducted this meta-analysis to investigate this association. We searched PubMed and Embase databases through December 31, 2014, and examined the references of retrieved articles to identify relevant cohort studies. We utilized Newcastle-Ottawa scale to assess the quality of included studies and calculated the summary risk estimates in a fixed/random-effect model. All data analyses were conducted using STATA version 11.0. A total of seven studies were identified. Compared with participants with an inter-arm SBPD < 10 mmHg, the pooled hazard ratio (HR) of CVD mortality of those with an inter-arm SBPD ≥ 10 mmHg was 1.58 (95% CI: 1.3-1.93), and the pooled HR of cardiovascular mortality of participants with an inter-arm SBPD ≥ 15 mmHg versus those with an inter-arm SBPD < 15 mmHg was 1.88 (95% CI: 1.33-2.66). The findings from the present meta-analysis indicated that the detection of an inter-arm SBPD may define a subpopulation at high risk of CVD events.
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Zhou et al. (2016) conducted a meta-analysis in Cardiovascular mortality. Inter-arm systolic blood pressure difference ≥ 10 mmHg vs. Inter-arm systolic blood pressure difference < 10 mmHg was evaluated on Cardiovascular mortality (HR 1.58, 95% CI 1.3-1.93). An inter-arm systolic blood pressure difference ≥ 10 mmHg was associated with an increased risk of cardiovascular mortality compared to < 10 mmHg (HR 1.58; 95% CI 1.3-1.93).
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