Key result
Transmitral A velocity, heart rate, and left ventricular size were independent determinants of corrected end-diastolic vortex flux in patients with LV dysfunction (R2=0.593, P<0.001).
Why the study?
The study was conducted to assess the factors influencing the late diastolic vortex in normal and abnormal ventricles.
What factors influence the end-diastolic vortex assessed by vector flow mapping in normal and abnormal ventricles?
Observational (n=167)
What factors influence the end-diastolic vortex assessed by vector flow mapping in normal and abnormal ventricles?
p-value: p=<0.001
The end-diastolic vortex is primarily influenced by late left ventricular filling, compensatory atrial contraction, and left ventricular size in patients with dysfunction.
May aid vortex interpretation in LV dysfunction; hypothesis-generating and requires prospective validation before clinical use.
Objectives The purpose of this study was to assess the factors influencing the late diastolic vortex in normal and abnormal ventricles. Methods Color Doppler data in left ventricle (LV) were acquired from apical long‐axis view and analyzed using vector flow mapping in 57 patients with coronary artery disease, 57 patients with dilated cardiomyopathy, and 53 healthy volunteers. Results In normals, corrected area and flux of the end‐diastolic vortex were positively correlated with transmitral A velocity and heart rate. Subjects with E/A <1 had higher vortex flux than those with E/A >1. Heart rate was the only independent predictor of corrected vortex area (R2 = .170, P = .004), and transmitral A velocity and heart rate were the independent predictors of corrected vortex flux (R2 = .490, P < .001). Patients with various mitral filling patterns showed significant differences in vortex area and flux. The vortex area and flux were positively correlated with transmitral i velocity and a′. Transmitral A velocity was the only independent predictor of corrected vortex area (R2 = .180, P < .001), while transmitral A velocity, heart rate, LV end‐systolic short diameter, and end‐diastolic long diameter were the independent determinants of corrected vortex flux (R2 = .593, P < .001). Conclusions The end‐diastolic vortex is formed and mainly affected by the late LV filling. The compensatory atrial contraction may enhance the end‐diastolic vortex that facilitates coupling between diastole and systole. LV size can influence the end‐diastolic vortex in patients with LV dysfunction and enlargement.
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Zhang et al. (2019) conducted an observational in Coronary artery disease, dilated cardiomyopathy, and healthy volunteers (n=167). Late left ventricular filling and left ventricular size was evaluated on Corrected area and flux of the end-diastolic vortex (p=<0.001). Transmitral A velocity, heart rate, and left ventricular size were independent determinants of corrected end-diastolic vortex flux in patients with LV dysfunction (R2=0.593, P<0.001).
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