Key result
Total serum thiol levels were significantly lower in patients with non-ST elevation acute coronary syndrome (388.41 µmol/l) compared to healthy controls (482.94 µmol/l).
Why the study?
Are total serum thiol levels lower in patients with NSTE-ACS compared to healthy controls, and can they differentiate between NSTEMI and unstable angina?
Case-Control (n=105)
No
Are total serum thiol levels lower in patients with NSTE-ACS compared to healthy controls, and can they differentiate between NSTEMI and unstable angina?
Absolute Event Rate: 388.41% vs 482.94%
p-value: p=<0.01
Total serum thiol levels are significantly reduced in patients with NSTE-ACS compared to healthy controls and are lower in NSTEMI than in unstable angina, suggesting potential utility as a diagnostic biomarker for oxidative stress in acute coronary syndromes.
Lower thiols in NSTE-ACS may mark oxidative stress; leaves open biomarker utility pending prospective validation.
Imbalance between antioxidant and oxidant systems in the body play an important role in the pathogenesis of coronary atherosclerosis and its complications. The aim of this clinical study was to investigate total serum thiol (TS-H) levels in patients with non ST Elevation Acute Coronary Syndrome (NSTE-ACS) patients and relationships between these results and cardiac markers. This study included 55 patients and a control group consisted of 50 healthy people. Samples for serum total TS-H levels were obtained from the patients considered with NSTE-ACS at the time of admission to emergency department. The patient group was divided into two subgroups according to troponin levels; that is patients with positive troponin levels in the non-ST-elevation myocardial infarction (NSTEMI) group and, and patients with negative troponin levels in the unstable angina pectoris (USAP) group. SPSS for Windows Ver. 15.0 software packages were used for statistical analysis of data in patient and control groups. The patients group included a total of 55 patients with 40 men (72.7%) and 15 women (27.3%) and the control group included 50 healthy individuals people with 28 men (56%) and 22 women (44%). Total serum TS-H values were significantly lower in patients group when compared with the control group. Serum total TS-H values were significantly lower in USAP subgroup when compared with patients with NSTEMI. In addition, negative correlations between total serum TS-H values and troponin I and CK-MB were found. According to this study, total serum levels of thiol which is antioxidant marker TS-H may be useful as a confirming test in diagnosis of patients with NSTE-ACS and in differentiating patients with NSTEMI and USAP.
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Tanrıverdi et al. (2014) conducted a case-control in Non-ST Elevation Acute Coronary Syndrome (NSTE-ACS) (n=105). Non-ST elevation acute coronary syndrome vs. Healthy controls was evaluated on Total serum thiol (TS-H) levels (p=<0.01). Total serum thiol levels were significantly lower in patients with non-ST elevation acute coronary syndrome (388.41 µmol/l) compared to healthy controls (482.94 µmol/l).
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