Key result
Lower thiol levels are linked to higher 6-month major cardiovascular events risk after primary PCI for STEMI.
Why the study?
The association between low thiol levels and peri-procedural factors during pPCI in STEMI patients and their prognostic value at 6 months was unclear.
Observational (n=308)
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Thiol levels may aid peri-procedural risk stratification in STEMI; leaves open causal links and need for interventional trials.
OBJECTIVE: The aim of this study was to investigate whether low thiol levels are associated with peri-procedural factors during primary percutaneous coronary intervention (pPCI) upon admission with ST-segment elevation myocardial infarction (STEMI), and the prognostic value at 6-month follow-up. METHODS: A total of 241 consecutive acute STEMI patients who underwent pPCI and a control group of 67 individuals with a normal coronary angiography were enrolled in the study. RESULTS: While age, contrast-induced nephropathy, N-terminal prohormone of brain natriuretic peptide (NT-proBNP), stent length, and creatinine were related to native thiol, NT-proBNP, contrast-induced nephropathy, and creatinine were related to total thiol. NT-proBNP was also related to the disulphide level. The left ventricular ejection fraction (LVEF) and the levels of native thiol, total thiol, low-density lipoprotein, and serum albumin were found to be independent predictors of major adverse cardiovascular events (MACEs) during 6 months of follow-up. CONCLUSION: Initial lower native thiol, total thiol, LVEF, LDL, and serum albumin may be used to identify patients with an increased long-term risk of unfavorable cardiac events in case of STEMI.
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Oğuz Akkuş (2018) conducted an observational in ST-segment elevation myocardial infarction (STEMI) (n=308). Low thiol levels vs. Higher thiol levels was evaluated on Major adverse cardiovascular events (MACEs). Lower native and total thiol levels were identified as independent predictors of major adverse cardiovascular events over a 6-month follow-up in patients with STEMI undergoing primary PCI.
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