Key result
The coxsackie and adenovirus receptor (CAR) functions as a key adhesion molecule controlling immune cell recruitment and tumorigenesis in both homeostatic and pathological states.
This review highlights the emerging role of the coxsackie and adenovirus receptor (CAR) beyond viral entry, specifically in cell adhesion, immune cell recruitment, and tumorigenesis.
CAR may guide immunomodulatory strategies in cancer and inflammation; leaves open targeted therapies pending clinical validation.
The coxsackie and adenovirus receptor (CAR) is a transmembrane receptor that plays a key role in controlling adhesion between adjacent epithelial cells. CAR is highly expressed in epithelial cells and was originally identified as a primary receptor for adenovirus cell binding. However, studies over the last 10 years have demonstrated that CAR plays a key role in co-ordinating cell-cell adhesion under homeostatic conditions including neuronal and cardiac development and cell junction stability; it has also been implicated in pathological states such as cancer growth and leukocyte transmigration during inflammation. Here we provide an overview of the functions of CAR as an adhesion molecule and highlight the emerging important role for CAR in controlling both recruitment of immune cells and in tumorigenesis.
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Ortíz-Zapater et al. (2017) reported a review. Coxsackie and adenovirus receptor (CAR) was evaluated. The coxsackie and adenovirus receptor (CAR) functions as a key adhesion molecule controlling immune cell recruitment and tumorigenesis in both homeostatic and pathological states.
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