Key result
The coxsackie B virus and adenovirus receptor (CAR) localizes to a novel lipid-rich microdomain distinct from caveolin-1-containing caveolae, determined by its cytoplasmic tail.
The coxsackie B virus and adenovirus receptor resides in a distinct lipid-rich microdomain determined by its cytoplasmic tail, facilitating its role in cellular adhesion and viral entry.
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May refine models of viral receptor trafficking in cardiomyocytes; leaves open clinical implications for human cardiac infections.
Excoffon et al. (2003) studied this question. CAR constructs (wt CAR, GPI-CAR, Tailless-CAR, CAR-LDLR) was evaluated on Cellular localization of CAR. The coxsackie B virus and adenovirus receptor (CAR) localizes to a novel lipid-rich microdomain distinct from caveolin-1-containing caveolae, determined by its cytoplasmic tail.
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