Key result
The solution structure and dynamic properties of monomeric CAR-D1 were determined by NMR spectroscopy at pH 3.0, providing insights into the monomer-dimer equilibrium and viral binding sites.
Population
Coxsackievirus and Adenovirus Receptor Domain 1 (CAR-D1)
Design
Preclinical
Authors
Loading...
Structural insights into CAR-D1 monomer may aid antiviral design; leaves open translation to human viral myocarditis therapies.
Determination of the CAR-D1 solution structure provides structural insights into how coxsackievirus and adenovirus bind to their cellular receptor.
Jiang et al. (2004) studied this question. The solution structure and dynamic properties of monomeric CAR-D1 were determined by NMR spectroscopy at pH 3.0, providing insights into the monomer-dimer equilibrium and viral binding sites.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: