Key result
The intracellular domain of the coxsackievirus and adenovirus receptor is required for canine adenovirus type 2 entry and transduction in fibroblast-like cells, but dispensable for human adenovirus type 5.
Population
Fibroblast-like cells
Comparison
Deletion or modification of the coxsackievirus… vs Intact CAR intracellular domain
Design
Preclinical
Authors
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Requires caution extrapolating CAR requirements across adenoviral vectors; extends entry models but needs in vivo validation.
The intracellular domain of the coxsackievirus and adenovirus receptor differentially regulates the entry and trafficking of different adenoviruses.
Loustalot et al. (2015) studied Adenovirus infection. CAR intracellular domain (ICD) deletion vs. Wild-type CAR / HAdV-C5 was evaluated on Viral entry and transduction efficiency. The intracellular domain of the coxsackievirus and adenovirus receptor is required for canine adenovirus type 2 entry and transduction in fibroblast-like cells, but dispensable for human adenovirus type 5.
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