February 24, 2007Protein ScienceOpen Access

Solution structure of the coxsackievirus and adenovirus receptor domain 2

Q: What is the clinical evidence from this study?

Primary outcome: Solution structure of CAR-D2.

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Key result

NMR spectroscopy revealed that CAR-D2 is a beta-sandwich motif comprised of two beta-sheets stabilized by two disulfide bonds, with a hydrophobic helix replacing beta-strand D.

Authors

SJShaokai JiangTianjin University MCMichael CaffreyUniversity of Arizona

Discussion

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Implication

Guides CAR functional studies; leaves open therapeutic targeting in viral myocarditis.

PICO

Primary Outcome

Solution structure of CAR-D2

Cite This Study

Jiang et al. (2007) studied this question. NMR spectroscopy revealed that CAR-D2 is a beta-sandwich motif comprised of two beta-sheets stabilized by two disulfide bonds, with a hydrophobic helix replacing beta-strand D.

synapsesocial.com/papers/6a97b703cfa25b768ec621fe https://doi.org/10.1110/ps.062643507

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Solution structure of the coxsackievirus and adenovirus receptor domain 2

Discussion

Member takes

Implication

PICO

Cite This Study

Solution structure of the coxsackievirus and adenovirus receptor domain 2

Discussion

Member takes

Implication

PICO

Cite This Study

Also Consider

Also Consider