Key result
Coxsackievirus and Adenovirus receptor domain 2 (CAR-D2) 1H, 13C, and 15N NMR resonances were successfully assigned and its secondary structure was deduced.
Population
Coxsackievirus and Adenovirus receptor domain 2 (CAR-D2)
Design
Preclinical
Authors
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NMR assignment of CAR-D2 enables future ligand studies; leaves open translation to viral myocarditis or gene therapy.
The study provides NMR resonance assignments and secondary structure information for the CAR-D2 domain, which mediates viral entry.
Jiang et al. (2005) studied this question. Coxsackievirus and Adenovirus receptor domain 2 (CAR-D2) 1H, 13C, and 15N NMR resonances were successfully assigned and its secondary structure was deduced.
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