Key result
Multiple regions within the coxsackievirus and adenovirus receptor (CAR) cytoplasmic domain contain information necessary for basolateral targeting in epithelial cells.
This basic science study identifies that multiple regions within the CAR cytoplasmic domain are required for its basolateral sorting in epithelial cells.
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Does not inform clinical decisions on viral infections; leaves open precise mapping of CAR targeting motifs for future studies.
Cohen et al. (2001) studied this question. CAR variants with progressive truncations and mutations vs. Wild-type CAR was evaluated on Localization of CAR variants on the cell surface. Multiple regions within the coxsackievirus and adenovirus receptor (CAR) cytoplasmic domain contain information necessary for basolateral targeting in epithelial cells.
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