Key result
Analysis of mammalian cardiac transcriptome and proteome data revealed that MYH7b RNA undergoes non-productive alternative splicing, preventing functional protein expression in the heart.
Why the study?
The biological contribution of sarcomeric myosin family member MYH7b in the heart remained debated after studies linked MYH7b variants to cardiomyopathies or reported protein expression.
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No functional MYH7b protein in mammalian hearts; leaves open its potential non-coding regulatory roles.
Lee et al. (2021) studied Cardiomyopathies. MYH7b RNA alternative splicing was evaluated on MYH7b protein expression. Analysis of mammalian cardiac transcriptome and proteome data revealed that MYH7b RNA undergoes non-productive alternative splicing, preventing functional protein expression in the heart.
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