Why the study?
Does platelet-activating factor stimulate the conversion of angiotensin I to II in pulmonary artery endothelial cells?
Does platelet-activating factor stimulate the conversion of angiotensin I to II in pulmonary artery endothelial cells?
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Platelet-activating factor significantly stimulates the conversion of angiotensin I to II in pulmonary artery endothelial cells, suggesting a novel interaction with the renin-angiotensin system.
We have studied the effects of platelet-activating factor (alkyl-acetyl-GPC) on conversion of angiotensin I to II. Platelet-activating factor (PAF) had a novel effect on angiotensin I conversion. Pulmonary artery endothelial cells converted 30% of [125I]angiotensin I to angiotensin II in the absence of PAF, but their activity was greatly stimulated in its presence. When PAF was added to pulmonary artery endothelial cells, the conversion of angiotensin I to II was enhanced up to 68%. Maximal stimulation without cellular damage was achieved at 10(-5) M PAF. LysoPAF did not stimulate the conversion of angiotensin I to angiotensin II at any concentration used.
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Kawaguchi et al. (1987) studied this question.
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