Key result
L-arginine administration lowered blood pressure and inhibited platelet aggregation in hypertensive rats, suggesting endogenous ADMA facilitates platelet aggregation via upregulation of plasma tissue factor.
Endogenous ADMA facilitates platelet hyperaggregation in hypertension by upregulating plasma tissue factor, an effect that can be mitigated by L-arginine.
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Does not support L-arginine use in hypertension; hypothesis-generating for ADMA effects in humans.
Li et al. (2011) studied Hypertension. L-arginine vs. Control animals was evaluated on Systolic blood pressure, platelet aggregation, and plasma tissue factor (TF) level and activity. L-arginine administration lowered blood pressure and inhibited platelet aggregation in hypertensive rats, suggesting endogenous ADMA facilitates platelet aggregation via upregulation of plasma tissue factor.
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