Key result
Preemptive analgosedation with ketamine-dexmedetomidine reduced pain on needle prick compared to ketamine-propofol (5.7% vs 42.9%) but increased nausea (28.6% vs 5.7%).
Why the study?
Analgosedation before and during regional anesthesia provides analgesia, anxiolysis, and amnesia, prompting a comparison of ketamine-dexmedetomidine versus ketamine-propofol for sedation, needle prick pain, hemodynamics, and side effects during supraclavicular brachial plexus block.
Does ketamine-dexmedetomidine improve sedation and reduce pain on needle prick compared to ketamine-propofol in patients undergoing upper limb surgeries under supraclavicular block?
Population
75 patients
Comparison
Ketamine-dexmedetomidine vs ketamine-propofol
Authors
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May favor ketamine-dexmedetomidine to minimize pain during supraclavicular block; extends sedation comparisons in regional anesthesia.
RCT (n=75)
Does ketamine-dexmedetomidine improve sedation and reduce pain on needle prick compared to ketamine-propofol in patients undergoing upper limb surgeries under supraclavicular block?
Absolute Event Rate: 5.7% vs 42.9%
Ketamine-dexmedetomidine provides adequate sedation and less pain on needle prick during supraclavicular block compared to ketamine-propofol, though it is associated with a higher incidence of nausea.
AjayGajanan Phatak (2022) conducted an RCT in Upper limb surgeries under supraclavicular brachial plexus block (n=75). Ketamine-dexmedetomidine vs. Ketamine-propofol was evaluated on Pain on needle prick while performing block. Preemptive analgosedation with ketamine-dexmedetomidine reduced pain on needle prick compared to ketamine-propofol (5.7% vs 42.9%) but increased nausea (28.6% vs 5.7%).
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