Population
7-week-old male Sprague-Dawley rats (isolated hearts/left ventricles)
Comparison
Solubilization using alkyaryl amidosulfobetaine… vs Solubilization using 3-[dimethylammonio]-1-propan…
Design
Preclinical
Authors
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C8psi yields no gain in total cardiac proteins versus CHAPS; leaves open potential for better subcellular resolution in future studies.
The detergent C8psi may improve the resolution of 2-D protein profiles for cardiac subcellular membrane-associated proteins compared to traditional surfactants.
Macri et al. (2000) studied this question.
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