Why the study?
Does overexpression of dominant negative mutant of c-Jun prevent cardiomyocyte hypertrophy induced by endothelin 1 and phenylephrine in cultured rat neonatal ventricular myocytes?
Population
Cultured rat neonatal ventricular myocytes
Comparison
Adenovirus vector overexpressing dominant… vs Cultured rat neonatal ventricular myocytes…
Design
Preclinical
Follow-up
48 hours
Authors
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Supports AP-1 mediation of hypertrophy in neonatal myocytes; leaves open translation to adult, in vivo, or clinical settings.
Does overexpression of dominant negative mutant of c-Jun prevent cardiomyocyte hypertrophy induced by endothelin 1 and phenylephrine in cultured rat neonatal ventricular myocytes?
Overexpression of a dominant negative mutant of c-Jun inhibits cardiomyocyte hypertrophy induced by endothelin 1 and phenylephrine, highlighting the role of AP-1 transcriptional activity in myocardial hypertrophy.
Omura et al. (2002) studied this question.
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