Key result
Chronic renal failure was associated with significantly higher serum PIP levels (1505.5 ng/mL) and more deteriorated left ventricular function compared to hypertension, diabetes mellitus, or normal controls.
Cross-Sectional (n=154)
No
Absolute Event Rate: 1505.5% vs 826.4%
p-value: p=<0.0001
In patients with left ventricular hypertrophy, chronic renal failure is associated with more severe LV dysfunction and higher levels of the myocardial fibrosis biomarker PIP compared to hypertension or diabetes.
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CRF may worsen LV function via fibrosis in LVH; hypothesis-generating and requires prospective validation before practice change.
Koh et al. (2009) conducted a cross-sectional in Left ventricular hypertrophy (n=154). Chronic renal failure vs. Hypertension, diabetes mellitus, and normal controls was evaluated on Serum carboxy-terminal propeptide of procollagen type I (PIP) level (ng/mL) (p=<0.0001). Chronic renal failure was associated with significantly higher serum PIP levels (1505.5 ng/mL) and more deteriorated left ventricular function compared to hypertension, diabetes mellitus, or normal controls.
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