Key result
Serum PIP levels were significantly higher in patients with low-LVEF heart failure compared to healthy controls (137 vs 86 μg/L), yielding an AUC of 0.984 for diagnosis.
Why the study?
Does serum PIP level accurately diagnose chronic heart failure with low LVEF compared to healthy controls?
Observational (n=167)
No
Does serum PIP level accurately diagnose chronic heart failure with low LVEF compared to healthy controls?
Effect estimate: AUC 0.984 (95% CI 0.951-0.997)
Absolute Event Rate: 137% vs 86%
p-value: p=<0.001
Serum PIP is a highly sensitive and specific biomarker for diagnosing low-LVEF heart failure, reflecting structural myocardial remodeling and fibrosis.
Serum PIP may aid low-LVEF HF diagnosis; hypothesis-generating and requires prospective validation before clinical use.
OBJECTIVE: The structural and compositional changes in the myocardium seem to have a major role in the development of heart failure (HF).Imbalance between production and degradation in extracellular collagen results in increase of collagen synthesis biomarkers in the circulation as the carboxy-terminal propeptide of type I procollagen (PIP). Here we aimed to determine role of PIP in the diagnosis of chronic HF. MATERIAL AND METHODS: 87 patients with HF group and 80 healthy subjects were enrolled into the study. Echocardiographic examination was performed.At the beginning of the study, serum B type natriuretic peptide (BNP), PIP, high sensitive C-reactive protein (hs-CRP) were measured . The subjects were followed for one year then after. RESULTS: Average PIP value of HF group was significantly higher than that of the control group (p < 0.001). Both hs-CRP and BNP values were well correlated to PIP values (p < 0.001). In the HF group, PIP value of patients who died at the end of one year was similar to that of patients who survived at the end of first year. CONCLUSION: PIP may not mirror acute events in follow-up of chronic heart failure but it is a very beneficial biomarker in diagnosis of low-LVEF heart failure with high sensitivity and specificity (Tab. 2, Fig. 1, Ref. 16).
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Demir et al. (2018) conducted an observational in Chronic heart failure with low LVEF (n=167). Elevated PIP (carboxy-terminal propeptide of type I procollagen) vs. Healthy subjects with normal LVEF was evaluated on Diagnostic accuracy of PIP for low-LVEF heart failure (AUC 0.984, 95% CI 0.951-0.997, p=<0.001). Serum PIP levels were significantly higher in patients with low-LVEF heart failure compared to healthy controls (137 vs 86 μg/L), yielding an AUC of 0.984 for diagnosis.
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