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A procedure has been developed for the synthesis of (2-methylquinolin-4-ylsulfanyl)-substituted acetic and propionic acids and propionitriles having methyl, methoxy, or carboxy groups or halogen atom in position 6 or 8 of the quinoline ring via reactions of the corresponding substituted 2-methylquinoline-4-thiols with chloroacetic or acrylic acid and acrylonitrile.
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Avetisyan et al. (2010) studied this question.
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